- Playstation
Play as Alien Saucer
Enter R1 Square X Square L2 Circle as a password.
Play as Big Daddy
Enter Triangle Square R2 X Triangle R2 as a password. Then select "Challenge" mode and choose the "Nuke York=" level to enable Big Daddy on the vehicle selection screen.
Play as Goliath
Enter Triangle L1 R1 X L2 L2 as a password.
Play as Nightshade
Enter R1 R2 L1 L1 X Circle as a password.
Play as Helicopter
Enter L1 Triangle R2 Triangle Triangle R1 as a password.
Funtopia Level
Enter X Circle L2 X Square L1 as a password to unlock the Funtopia level under challenge mode.
Gulch Level
Enter X Square Circle L1 L2 Square as a password to unlock the Gulch level under challenge mode. Alternately enter Square Square Triangle R1 L1 Circle as a password.
Boss Battle 1
Enter Circle R2 R1 Square L1 R2 as a password. Note: Reenter this password after every challenge battle. The first opponent will be a normal random character. Your opponent will transform into Goliath after the battle.
Boss Battle 2
Enter Circle Circle L2 L1 Triangle Triangle as a password.
Boss Battle with Big Daddy
Enter Square Triangle Circle Circle R2 R2 as a password.
Double PickUps
Enter L1 L2 Circle L1 R1 Square as a password.
Increased Armor
Enter R1 Triangle R1 Triangle L1 Square as a password.
Infinite Turbos
Enter Square X Circle Triangle R1 R2 as a password. Note: The special bar will still decrease but turbos will still be available after it runs out.
Infinite Jump
Enter Circle Square R2 X Triangle R2 as a password.
View Duke Nukem: Time to Kill FMV
Enter Square Square Circle Circle Triangle Triangle as a password.
Alternate Views
While playing a game in one player mode hold R1 Select and press Down to switch to an overhead and helicopter view. In two player mode this will alternate how the screen is split.
Remove All Items From Screen
While playing a game hold R1 Select and press Up to have a full screen view.
Cheat Mode
While playing a game hold L1 R1 R2 and press Select to enable cheat mode. If you entered the code correctly "Cheats Enabled=" will appear at the top of the screen. Now you may enter any of the following "Codes":
| Effect | Code |
| God Mode | Hold L1 R1 R2 and press Up Down Left Right |
| Invulnerable | Hold L1 R1 and press Up Down Left Right |
| Infinite Weapons | Hold L1 R1 and press Up Down Up R2 |
| PoweredUp Weapons | Hold L1 R1 R2 X and press Down |
| Hornet Nest Stingers | Select Stingers then press L1 L2 R1 Triangle Left |
