Let's Play Heroes is a retro-style beat-'em-up with light RPG elements. Like the television show from which it was spun off, Let's Play Heroes is set in the town of Lakewood Plaza and stars KO, an aspiring superhero who works at a convenience store for other superheroes. As KO, players fight through side-scrolling stages and acquire POW cards, which allow them to call in other characters from the series for a powerful attack.