Dishonored 2 could turn out to be the next Just Cause 3. That is, over a year on from release, you wouldn't be able to play a pirated version - because Dishonored 2 is making use of the Denuvo anti-tamper system.
Denuvo has been the bane of game crackers and pirates the world over the past couple of years, making it impossible to breach copy protection on them for weeks, months and in the case of games like Just Cause 3, more than a year. It works as an anti-tamper technology, rather than copy protection in its own right. It protects traditional DRM like SECUROM, adding a secondary layer of protection, that doesn't impede the use of the software for legitimate users.
It's rather clever that way and has proved almost impossible to crack.
However, recently some release teams were able to breach its protective shell in the case of a few games, suggesting that its days were numbered. But there was no snowball effect, no avalanche of cracked games. In fact the Denuvo developers admit that they will probably be cracked at some point and never claim to be unbreakable - as so many DRM makers have claimed to their peril in the past.
Instead, Denuvo just quietly updates its system and goes back to working, protecting games from being cracked. That's why it's become part of Dishonored 2 and will likely protect it for a few weeks after launch, which is the most important time frame any way.