Resident Evil 4 - Easy kills

Good handguns:
In terms of power, the Red 9 is the most powerful handgun. It has about power 6 or 8 when you get the exclusive upgrade for it. It has decent speed, and good capacity 20 rounds full upgrade. The Punisher is good for crowd control because of the penetrating rounds, but otherwise use the Red 9. The normal 9mm Handgun in the beginning is average, although it is best with headshots because the exclusive upgrade raises the critical headshot ratio. The Blacktail has no obvious weaknesses or strengths, and is a very versatile gun. The best handgun is the Red 9. Its power, speed, and lots of ammunition make it a very good choice. Fully upgraded, the Red 9 has about the power of the shotgun in every round.

Easy money:
Once you gain access to the tunnel with the merchant beyond Pueblo, return to the farm area and wait for the chickens there to lay eggs. Exit and re-enter to begin the same process over again. After you fill your inventory, you can return to the nearby merchant to sell your eggs. White chicken eggs sell for 300 Pesetas, brown eggs for 600 Pesetas, and golden eggs for 3,000 Pesetas.

Handcannon:
Get a five star rank with all mercenaries to unlock the Handcannon weapon. To get unlimited ammunition for it, fully upgrade all of the Handcannon's options. Successfully complete the game two times. The Handcannon will be available as soon as you start the game again for 0 Pesetas. It is a very powerful magnum, and will have unlimited ammunition. When you go to upgrade it in the merchant window, in the "Handcannon" update screen there is an option labeled "Exclusive". When chosen, the gun is upgraded with power identical to the Chicago Typewriter.

Killing birds:
Toss a flash grenade in the center of a group of birds. All of them will die instantly, leaving lots of Pesetas. This also works with the Granadas when their heads are transformed.

Game trailers:
Remain idle at the title screen. Eventually two trailers will begin playing and begin to cycle.

Mercenaries mini-game - Items and ammunition:
Leon Kennedy
Handgun Ammo x30
Shotgun Shell x10
First Aid Spray x1

Ada Wong
Handgun Ammo x30
TMP Ammo x100
Rifle Ammo x5
Scope semi-auto rifle x1
Incendiary Grenade x3
First Aid Spray x1

Jack Kauser
Arrows x30
Flash Grenade x3
First Aid Spray x1

Hunk
TMP Ammo x50
Hand Grenade x3
First Aid Spray x1

Albert Wesker
Hand Grenade x4
Flash Grenade x3
Incendiary Grenade x1
Silencer Handgun x1
First Aid Spray x1

Alternate ending sequence:
Successfully complete Assignment Ada and watch the credits. They will be in gray scale. However, if you select "Yes" when asked "Watch the ending movie again?", it will be replayed in color in a smaller frame. If you watch it once more when prompted, it will play is full wide screen color. They will alternate each time you choose to replay the credits.

Gaining health:
Before you fight Del Lago, walk onto the dock where the speedboat is found. You can fire at Black Bass. Take the boat out to recover them. However, be careful; if you fire too many shots Del Lago will eat you at the end of the dock.

Defeating Bosses:
To defeat Chief Mendez, Verdugo, Krauser, the U3 experiment "It", and Saddler, all in one second, immediately at the start of the battle take out the PRL 412 laser cannon. Use the laser-light flash and they will die instantly, without having to reveal their weak spot or freezing them, even under the professional difficulty setting. Note: You cannot kill a Gigante until its parasite is showing. If you read the description of the gun, it says that it is made to harm just parasites. However, a charged blast of the PRL 412 is just as strong as a rocket; use that on a Gigante, then stand close to it and use the flash. You also cannot kill Salazar with this strategy because he is too far away for the flash, but not for the charged blast. Because of his spine, Chief Mendez can be defeated in only three seconds with this strategy.

Completion bonuses:
Successfully complete the game to unlock the Separate Ways and Mercenaries-mini-games; the Professional difficulty setting; the Leon's Raccoon City Police Department costume, Ashley's pop star costume, and Ada's black costume; the Mathilda handgun and Infinite Rocket Launcher for purchase for 1 million Pesetas, and the Tactical Vest for 60,000 Pesetas; and an alternate title screen.